Description

Chronic lead exposure can increase the risk of gout through its effects on kidney function and uric acid metabolism. Lead interferes with the normal functioning of the proximal renal tubules, which are responsible for uric acid excretion. This interference can lead to decreased uric acid clearance and subsequent hyperuricemia. Additionally, lead exposure may increase the production of reactive oxygen species, contributing to oxidative stress and inflammation, which can exacerbate gout symptoms. Occupational exposure to lead, such as in battery manufacturing, construction, and certain industrial processes, is a significant risk factor. Even low levels of chronic lead exposure, previously considered safe, may contribute to gout risk. A study published in the Annals of Internal Medicine found that low-level lead exposure was associated with higher uric acid levels and an increased prevalence of gout [1]. Another research article in Environmental Health Perspectives demonstrated a dose-response relationship between blood lead levels and the risk of gout in the general population [2]. These findings underscore the importance of lead exposure prevention and screening in gout risk assessment, particularly in occupationally exposed individuals.