Description

Some medications can increase uric acid levels and potentially trigger gout attacks. Diuretics, commonly used to treat high blood pressure and heart failure, can reduce uric acid excretion by the kidneys, leading to hyperuricemia. Low-dose aspirin, while beneficial for cardiovascular health, can also affect uric acid levels at certain dosages. Some immunosuppressants used in organ transplantation, such as cyclosporine, can increase uric acid production. Beta-blockers and angiotensin-converting enzyme (ACE) inhibitors may also affect uric acid metabolism. A comprehensive review published in Therapeutic Advances in Chronic Disease highlighted the various medications that can influence uric acid levels and gout risk [1]. A study in the Journal of Rheumatology found that diuretic use was associated with a significantly increased risk of recurrent gout attacks [2]. It's important for patients with gout to discuss their medications with their healthcare provider to assess the potential impact on their condition.