Description

Undergoing surgery can sometimes trigger gout attacks through various physiological mechanisms. The stress of surgery activates the body's inflammatory response, which can lead to changes in uric acid metabolism and excretion. During surgery, tissue breakdown and cellular destruction can release purines into the bloodstream, potentially increasing uric acid levels. Additionally, fasting before surgery and reduced fluid intake during the perioperative period can lead to dehydration, further concentrating uric acid in the blood. Certain medications used during surgery, such as diuretics, can also affect uric acid levels. A study published in Arthritis Research & Therapy found that the risk of gout flares increased significantly in the post-operative period, with the highest risk observed within the first 3 days after surgery [1]. Another study in the Journal of Rheumatology demonstrated that patients with a history of gout were at higher risk of post-operative gout flares, suggesting the need for preventive strategies in this population [2].