Description

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to manage pain and inflammation associated with acute gout attacks. It works by inhibiting cyclooxygenase enzymes, reducing the production of prostaglandins responsible for pain and inflammation. A randomized controlled trial by Janssens et al. (2008) found that naproxen was as effective as prednisolone in treating acute gout flares, with similar pain reduction and recovery times. However, naproxen and other NSAIDs carry risks of gastrointestinal and cardiovascular side effects, particularly with long-term use. A meta-analysis by Kearney et al. (2006) highlighted the increased risk of myocardial infarction associated with high-dose NSAID use. Therefore, naproxen should be used at the lowest effective dose for the shortest possible duration, especially in patients with cardiovascular risk factors or a history of gastrointestinal ulcers.