Description

Increasing vitamin C intake through diet or supplementation has been shown to have potential benefits in gout management. A prospective study by Choi et al. (2009) in the Archives of Internal Medicine found that higher vitamin C intake was associated with a lower risk of gout. The study demonstrated that men with vitamin C intake of 1,500 mg or more per day had a 45% lower risk of gout compared to those with intake less than 250 mg per day. A meta-analysis by Juraschek et al. (2011) in Arthritis Care & Research showed that vitamin C supplementation was associated with a significant reduction in serum uric acid levels. The mechanism of action was explored in a review by Mikirova et al. (2013), which explained how vitamin C can increase uric acid excretion and potentially reduce inflammation. However, it's important to note that while vitamin C may have beneficial effects, its impact may be modest compared to other interventions. A randomized controlled trial by Stamp et al. (2013) found that vitamin C supplementation had a small effect on serum urate in patients with gout. The ACR guidelines (Khanna et al., 2012) conditionally recommend vitamin C supplementation for gout patients, suggesting a typical dose of 500-1,000 mg daily.